When it comes to opiates, just say NO

When it comes to opiates, just say NO.

Repeated use of opiate analgesic drugs such as morphine for the relief of chronic pain may result in the development of opiate tolerance and dependence, leading to a narrowing of the drug's therapeutic index and increased side effects. Previous preclinical work has shown that interruption of a signaling cascade involving the N-methyl-D-aspartate receptor and NO prevents morphine tolerance. In t...

When it comes to antibiotics, bacteria show some NO-how.

Homologs to mammalian nitric oxide synthases are found in many mostly Gram-positive bacteria. In some genera such as bacilli, and staphylococci, these enzymes produce protects against oxidative damage, this effect has now been shown to provide an advantage against antibiotics that kill by increasing cellular levels of reactive oxygen species.

Sleep medicine: no sleeper when it comes to profits.

• Increased consumer focus on sleep by education, regulation and patient selfawareness.7 Sleep medicine is a relatively new field that was officially recognized in the 1960s. Today, an estimated 50 million to 70 million Americans suffer from sleep-related problems.1 The first sleep disorder clinic was opened in 19702 at Stanford University by William Dement, MD. Today more than 2,000 sleep cent...

It’s not just what you say but when you say it: Self-presentation and temporal construal

Three experiments demonstrated that the use and effectiveness of self-presentation strategies are affected by time. In Experiment 1, participants used more indirect self-presentation statements for the distant than near future, but used more direct self-presentation statements for the near than distant future. In Experiment 2, participants for whom indirect self-presentation strategies were mad...

When It Comes to Clethra: Roots Matter